abstract：BACKGROUND:There are multiple therapeutic options for the treatment of moderate to severe psoriasis. The process of choosing among potential treatment options requires both the physician and the patient to weigh the benefits of individual modalities against their potential risks. Traditional systemic therapies for psor...

journal_title：Journal of the American Academy of Dermatology

authors： Patel RV,Clark LN,Lebwohl M,Weinberg JM

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Nonmelanoma skin cancer (NMSC) incidence in patients with vitiligo has not been studied. OBJECTIVE:We sought to quantify the incidence of NMSC in patients with vitiligo. METHODS:A cohort of 477 patients with vitiligo and no history of NMSC seen in an outpatient academic center between January 2001 and Dece...

journal_title：Journal of the American Academy of Dermatology

authors： Hexsel CL,Eide MJ,Johnson CC,Krajenta R,Jacobsen G,Hamzavi I,Lim HW

更新日期：2009-06-01 00:00:00

abstract：:The advent of electron microscopy and immunohistochemical stains allowed for reclassification of the histiocytoses based on the predominant cell in the infiltrate. Although the current schema simplicity provides a good foundation, some patients display overlapping clinical and immunohistochemical features that defy cl...

journal_title：Journal of the American Academy of Dermatology

authors： Satter EK,Gendernalik SB,Galeckas KJ

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Gorlin-Goltz syndrome (GGS) is an autosomal-dominant disease characterized by the early onset of multiple basal cell carcinomas (BCCs), among other findings. Clinically, the BCCs may appear as soft pedunculated neoplasms that can be mistaken for true acrochordons. OBJECTIVE:We sought to describe the dermato...

journal_title：Journal of the American Academy of Dermatology

authors： Feito-Rodríguez M,Sendagorta-Cudós E,Moratinos-Martínez M,González-Beato MJ,de Lucas-Laguna R,Pizarro A

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Few studies have reported the accuracy of measures used to assess sun-protection practices. Valid measures are critical to the internal validity and use of skin cancer control research. OBJECTIVES:We sought to validate self-reported covering-up practices of pool-goers. METHODS:A total of 162 lifeguards and...

journal_title：Journal of the American Academy of Dermatology

authors： O'Riordan DL,Nehl E,Gies P,Bundy L,Burgess K,Davis E,Glanz K

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:B-cell chronic lymphocytic leukemia (B-CLL) is a low-grade lymphoproliferative disorder with characteristic histomorphologic features and an identifiable immunophenotype. The skin can be involved in the context of known disease, but cutaneous signs are rarely the presenting findings. OBJECTIVE:Evaluation of...

journal_title：Journal of the American Academy of Dermatology

authors： Plaza JA,Comfere NI,Gibson LE,Colgan M,Davis DM,Pittelkow MR,Colgan JP

更新日期：2009-05-01 00:00:00

abstract：:We report a male infant with Down syndrome who had a transient myeloproliferative disorder associated with skin lesions. He was transferred to a neonatal intensive care unit because of low body weight, fetal edema, disseminated intravascular coagulation, and 10% blast cells in the peripheral blood. On postnatal day (P...

journal_title：Journal of the American Academy of Dermatology

authors： Uhara H,Shiohara M,Baba A,Shiohara J,Saida T

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that ultraviolet (UV) A1 phototherapy is an effective treatment for localized scleroderma (LS); however, the optimum UVA1 dose remains to be determined. OBJECTIVE:We sought to compare the immediate and long-term efficacy of low- versus medium-dose UVA1 phototherapy for plaque-type LS....

journal_title：Journal of the American Academy of Dermatology

authors： Sator PG,Radakovic S,Schulmeister K,Hönigsmann H,Tanew A

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Treatment of chronic discoid lupus erythematosus (CDLE) with a pulsed dye laser (PDL) has shown promising results, although outcomes in previous studies were not validated and laser parameters were inconsistent. OBJECTIVE:We conducted an open prospective study to assess the efficacy and safety of PDL for th...

journal_title：Journal of the American Academy of Dermatology

authors： Erceg A,Bovenschen HJ,van de Kerkhof PC,de Jong EM,Seyger MM

更新日期：2009-04-01 00:00:00

abstract：:Long-term penicillamine therapy has been associated with alterations in dermal elastic tissue. Well-described associated dermatoses include pseudo-pseudoxanthoma elasticum, acquired cutis laxa, elastosis perforans serpiginosa, and anetoderma. Histologically, "lumpy-bumpy" or "bramble-bush" morphologic changes of elast...

journal_title：Journal of the American Academy of Dermatology

authors： Lewis BK,Chern PL,Stone MS

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare and severe cutaneous adverse reactions to medications and infections. OBJECTIVE:We sought to determine whether a seasonal variation to SJS and TEN exists and to define the characteristics in our tertiary referral hospital. METHODS...

journal_title：Journal of the American Academy of Dermatology

authors： Wanat KA,Anadkat MJ,Klekotka PA

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:We sought to determine what clinical features of psoriasis predict sleep interference. METHODS:Data were obtained from 420 respondents to the 2005 National Psoriasis Foundation telephone and e-mail surveys. Logistic regression was used to determine whether disease severity, body mass index, age of onset, pso...

journal_title：Journal of the American Academy of Dermatology

authors： Callis Duffin K,Wong B,Horn EJ,Krueger GG

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Skin ulcers are common vascular complications of systemic sclerosis (SSc). OBJECTIVE:The aim of the study was to identify clinical, biologic, and imaging parameters that constitute risk factors for the occurrence and persistence of skin ulcers. METHODS:One hundred thirty Italian SSc patients were examined ...

journal_title：Journal of the American Academy of Dermatology

authors： Alivernini S,De Santis M,Tolusso B,Mannocci A,Bosello SL,Peluso G,Pinnelli M,D'Antona G,La Torre G,Ferraccioli G

更新日期：2009-03-01 00:00:00

abstract：UNLABELLED:Mycophenolate mofetil (MMF) is the prodrug of mycophenolic acid (MPA), a medication used to treat psoriasis in the 1970s until side effects and the concern of carcinogenesis led to its discontinuation. The prodrug, MMF, emerged decades later in the transplant field. Dermatologists have since used MMF off-lab...

journal_title：Journal of the American Academy of Dermatology

authors： Orvis AK,Wesson SK,Breza TS Jr,Church AA,Mitchell CL,Watkins SW

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:The efficacy of combination therapy with topical corticosteroids and tacrolimus in the treatment of atopic dermatitis remains to be established. OBJECTIVE:Our aim was to determine whether a regimen of sequential application of topical corticosteroids and topical tacrolimus is effective in the treatment of p...

journal_title：Journal of the American Academy of Dermatology

authors： Kubota Y,Yoneda K,Nakai K,Katsuura J,Moriue T,Matsuoka Y,Miyamoto I,Ohya Y

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Phototherapy may be effective in atopic dermatitis (AD). Medium-dose (MD) ultraviolet (UV) A1 was introduced for the treatment of AD. Few immunohistochemical data are available pertaining to phototherapy in AD. Regulatory T cells may play a role in clearing AD. OBJECTIVES:We sought to compare the clinical a...

journal_title：Journal of the American Academy of Dermatology

authors： Majoie IM,Oldhoff JM,van Weelden H,Laaper-Ertmann M,Bousema MT,Sigurdsson V,Knol EF,Bruijnzeel-Koomen CA,de Bruin-Weller MS

更新日期：2009-01-01 00:00:00

abstract：:The term Richter syndrome (RS) describes the transformation of chronic lymphocytic leukemia into a high-grade lymphoma. RS occurs in 3% to 10% of chronic lymphocytic leukemia cases, and its onset is often characterized by the abrupt development of systemic symptoms (eg, fever in the absence of infection, night sweats,...

journal_title：Journal of the American Academy of Dermatology

authors： Yamazaki ML,Lum CA,Izumi AK

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Condyloma acuminatum are common lesions caused by human papillomavirus (HPV). HPV is associated with many human cancers, and a vaccine now prevents infection with high-risk HPV. However, eradication of established disease is difficult, indicating that these lesions are capable of local immunosuppression. OB...

journal_title：Journal of the American Academy of Dermatology

authors： Le Poole C,Denman CJ,Arbiser JL

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Electronic claims and medical record databases are increasingly used for observational studies of psoriasis. The purpose of this study was to assess the validity of psoriasis diagnostic codes in an electronic database. METHODS:This study was performed in a population-based setting in Olmsted County, Minneso...

journal_title：Journal of the American Academy of Dermatology

authors： Icen M,Crowson CS,McEvoy MT,Gabriel SE,Maradit Kremers H

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Symptomatic dermographism is the most common type of physical urticaria. It can be severe and poorly controlled with H1 antihistamines in some patients. Photochemotherapy (psoralen plus ultraviolet [UV] A) may help the itch of dermographism but the effect of narrowband (NB) UVB therapy has not been previousl...

journal_title：Journal of the American Academy of Dermatology

authors： Borzova E,Rutherford A,Konstantinou GN,Leslie KS,Grattan CE

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Erythema induratum of Bazin is a mostly lobular panniculitis. There is considerable controversy in the literature about whether or not vasculitis is a histopathologic requirement to establish the diagnosis of erythema induratum of Bazin. Even accepting vasculitis as a histopathologic criterion, there is no a...

journal_title：Journal of the American Academy of Dermatology

authors： Segura S,Pujol RM,Trindade F,Requena L

更新日期：2008-11-01 00:00:00

abstract：:A combination of topical and oral antifungals is widely used to treat onychomycosis, but treatment failure is common and oral drugs may cause toxicity and potential drug interactions. For this reason, new approaches and strategies should be considered. The following case shows that photodynamic therapy (PDT) may repre...

journal_title：Journal of the American Academy of Dermatology

authors： Piraccini BM,Rech G,Tosti A

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Current treatments for vitiligo, a common pigmentary disorder affecting around 1% of the world's population, are largely unsatisfactory. OBJECTIVE:We sought to report a Cochrane review of all interventions for the treatment of vitiligo. METHODS:We systematically searched a range of databases for randomized...

journal_title：Journal of the American Academy of Dermatology

authors： Whitton ME,Ashcroft DM,González U

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:There are large discrepancies in reported mortality for bullous pemphigoid (BP). OBJECTIVE:We sought to determine the mortality of a large cohort of patients with BP and compare this with age-matched control subjects. METHODS:Data were collected on 223 patients with a new diagnosis of BP between 1998 and 2...

journal_title：Journal of the American Academy of Dermatology

authors： Parker SR,Dyson S,Brisman S,Pennie M,Swerlick RA,Khan R,Manos S,Korman BD,Xia Z,Korman NJ

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Reducing people's exposure to ultraviolet radiation is the primary strategy for skin cancer prevention. OBJECTIVE:We sought to provide comprehensive national data on preventive behaviors and risk assessment for Australia. METHODS:A national survey was conducted in summer 2003-2004. In 8 weekly cross-sectio...

journal_title：Journal of the American Academy of Dermatology

authors： Dobbinson S,Wakefield M,Hill D,Girgis A,Aitken JF,Beckmann K,Reeder AI,Herd N,Fairthorne A,Bowles KA

更新日期：2008-10-01 00:00:00

abstract：:This case describes an unusual presentation of dermatomyositis in a patient with ovarian carcinoma. The eruption appeared as a venous stasislike dermatitis. The temporal sequence of onset after chemotherapy administration suggested a possible drug-induced process. However, in the context of underlying ovarian carcinom...

journal_title：Journal of the American Academy of Dermatology

authors： Seidler AM,Wasserman DI,González-Serva A,Konnikov N

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:A scattered generalized distribution (SGD) of dermatitis is a challenging problem; patch testing is a strategy for evaluating allergic contact dermatitis as a relevant factor. OBJECTIVE:We sought to analyze patient characteristics and most frequently relevant positive allergens in patients presenting for pa...

journal_title：Journal of the American Academy of Dermatology

authors： Zug KA,Rietschel RL,Warshaw EM,Belsito DV,Taylor JS,Maibach HI,Mathias CG,Fowler JF Jr,Marks JG Jr,DeLeo VA,Pratt MD,Sasseville D,Storrs FJ

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:It is unsettled whether small plaque parapsoriasis (SPP) represents an inflammatory dermatosis or has a potential to transform into mycosis fungoides (MF) or is, in fact, MF. The literature contains no fully documented example of progression of SPP into MF. OBJECTIVE:The purpose of our study was to present ...

journal_title：Journal of the American Academy of Dermatology

authors： Belousova IE,Vanecek T,Samtsov AV,Michal M,Kazakov DV

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:We sought to develop a validated, reliable pruritus-specific quality-of-life (QOL) instrument, ItchyQoL. METHODS:From 21 in-depth interviews with patients with pruritus, we developed 22 pruritus-specific items, and hypothesized 3 major constructs that explain the way pruritus affects patients' QOL: symptoms,...

journal_title：Journal of the American Academy of Dermatology

authors： Desai NS,Poindexter GB,Monthrope YM,Bendeck SE,Swerlick RA,Chen SC

更新日期：2008-08-01 00:00:00

abstract：:In patients with psoriasis, there is an increased availability of drugs for treatment. However, there are important questions about drug safety for mothers with psoriasis and their fetuses. Currently, there are limited safety data for many of the medications used. In this article, we review current pregnancy risk info...

journal_title：Journal of the American Academy of Dermatology

authors： Lam J,Polifka JE,Dohil MA

更新日期：2008-08-01 00:00:00

abstract：:Dialogues in Dermatology, a monthly audio program from the American Academy of Dermatology, contains discussions between dermatologists on timely topics. Commentaries from Dialogues Editor-in-Chief Warren R. Heymann, MD, are provided after each discussion as a topic summary and are provided here as a special service t...

journal_title：Journal of the American Academy of Dermatology

authors： Heymann WR

更新日期：2008-08-01 00:00:00

abstract：:Histoplasma capsulatum and Trichosporon inkin may cause disseminated disease in immunocompromised patients. Disseminated T inkin, the causative agent of white piedra, is rare and difficult to diagnose. We report the case of a 28 year-old man with newly diagnosed HIV infection who developed asymptomatic lesions on his ...

journal_title：Journal of the American Academy of Dermatology

authors： David C,Martin DB,Deng A,Cooper JZ

更新日期：2008-08-01 00:00:00

abstract：:Capecitabine, an oral fluoropyrimidine and 5-fluorouracil (FU) prodrug recently approved for the treatment of metastatic colon and breast cancer, is currently under investigation in patients with gastric cancer. It has the advantage of oral administration, and good tolerability with its activity being comparable with ...

journal_title：Journal of the American Academy of Dermatology

authors： Weger W,Kränke B,Gerger A,Salmhofer W,Aberer E

更新日期：2008-08-01 00:00:00

abstract：:Dermatomyositis (DM) is an idiopathic inflammatory myopathy. The mainstay of treatment for DM is oral corticosteroids. However, the dose and length of treatment is debated. Adding to the confusion, there have been no randomized controlled studies comparing the use of various corticosteroid doses and taper rates, and n...

journal_title：Journal of the American Academy of Dermatology

authors： Iorizzo LJ 3rd,Jorizzo JL

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Since publication in 2000 of the Second International Consensus Report on Diagnosis and Classification of Epidermolysis Bullosa, many advances have been made to our understanding of this group of diseases, both clinically and molecularly. At the same time, new epidermolysis bullosa (EB) subtypes have been de...

journal_title：Journal of the American Academy of Dermatology

authors： Fine JD,Eady RA,Bauer EA,Bauer JW,Bruckner-Tuderman L,Heagerty A,Hintner H,Hovnanian A,Jonkman MF,Leigh I,McGrath JA,Mellerio JE,Murrell DF,Shimizu H,Uitto J,Vahlquist A,Woodley D,Zambruno G

更新日期：2008-06-01 00:00:00

abstract：:Arthropod bites remain a major cause of patient morbidity. These bites can cause local or systemic effects that may be infectious or inflammatory in nature. Arthropods, notably insects and arachnids, are vectors of potentially serious ailments including malaria, West Nile virus, dengue, and Lyme disease. Measures to c...

journal_title：Journal of the American Academy of Dermatology

authors： Katz TM,Miller JH,Hebert AA

更新日期：2008-05-01 00:00:00

abstract：:It is well established that ultraviolet (UV) radiation from sunlight damages skin cells' DNA. Wavelengths in the UVB range are absorbed by DNA and can induce mutagenic lesions such as pyrimidine dimers. On the other hand, genotoxic effects of solar UVA are mainly mediated by the activation of endogenous photosensitize...

journal_title：Journal of the American Academy of Dermatology

authors： Marrot L,Meunier JR

更新日期：2008-05-01 00:00:00

abstract：:Cannabis arteritis is a serious peripheral vascular disease affecting young adults consuming cannabis. An increasing number of cases have been recently reported in Europe. The risk of amputation is high. Cannabis arteritis is often confused with atherosclerosis. We present a new case in which complete arterial revascu...

journal_title：Journal of the American Academy of Dermatology

authors： Noël B,Ruf I,Panizzon RG

更新日期：2008-05-01 00:00:00

abstract：:Psoriasis is a common, chronic, inflammatory, multisystem disease with predominantly skin and joint manifestations affecting approximately 2% of the population. In this first of 5 sections of the guidelines of care for psoriasis, we discuss the classification of psoriasis; associated comorbidities including autoimmune...

journal_title：Journal of the American Academy of Dermatology

authors： Menter A,Gottlieb A,Feldman SR,Van Voorhees AS,Leonardi CL,Gordon KB,Lebwohl M,Koo JY,Elmets CA,Korman NJ,Beutner KR,Bhushan R

更新日期：2008-05-01 00:00:00

abstract：:Dialogues in Dermatology, a monthly audio program from the American Academy of Dermatology, contains discussions between dermatologists on timely topics. Commentaries from Dialogues Editor-in-Chief Warren R. Heymann, MD, are provided after each discussion as a topic summary and are provided here as a special service t...

journal_title：Journal of the American Academy of Dermatology

authors： Heymann WR

更新日期：2008-04-01 00:00:00